The 40-year-old sexy single burst out laughing when someone took a swipe at her douchebag ex John Mayer at the Women in Film Awards in California recently.
"You have increased the visibility of women in film, and we thank you for that," said Chelsea Handler while presenting Jen with an award.
"You've recently decreased the visibility of John Mayer, so we thank you for that."
Meow! A witness told Usmagazine.com that "Jen threw her head in her hands and was laughing so hard" at the dig.
"Her two girlfriends on either side started laughing hysterically."
When accepting the gong (which was a Crystal Award for Excellence in Film, by the way), Jen remarked, "I have a strange parallel with movies I was doing and my life off screen.
First, it was The Good Girl... which evolved into Rumor Has It, followed by Derailed" - a reference to her one-time marriage to Brad Pitt, perhaps?
"Then there was The Breakup," she continued. "Followed by the lighter side, Friends With Money.
"If anyone has a movie called Everlasting Love With an Adult Stable Man, that would be great!" she laughed.
"I'm at table six, and my agents are at table 12."
Loving the crap out of that! Check out Jennifer's evolution from geeky teen to Hollywood glamour girl in our gallery!