The usually inseparable pair, who starred together in the Charlie's Angels remakes, were both at the ceremony - and didn't say a word to each other all night.
"Both Cameron and Drew were at the party but neither one spoke to each other,” a source told OK! magazine. “They were on opposite sides of the room the entire night.”
Cameron has since gotten serious with boyfriend Paul Sculfor, which could be a factor in their growing apart. But hang on - when she dated Justin Timberlake there was no icyness on the BFF front!