UK paper The Sun exclusively reported that the couple are about to go public with their split by releasing a statement, because they "can’t bear to live with the pretence any longer".
Quarrels over the time each other spend working, and Madonna wanting to adopt another child, are said to be some of the reasons behind their unhappy marriage, which would have seen an eighth anniversary in December.
"It’s very sad," said The Sun's 'highly placed' source. "They were a great couple and brilliant parents. They just couldn’t live together any more."
“Despite huge attempts to patch things up they both knew deep down that divorce was on the cards. It wasn’t a matter of ‘if’ but ‘when’. They tried hard over the last few months but their fighting was getting out of control."
Madonna reporteldy wanted to wait until the end of her 'Sticky And Sweet' tour to announce their separation, but the couple are said to be aiming for a finalised divorce by Christmas.
“Guy said if they were going to split, it has to be now — and their marriage will finally be over in a matter of weeks," the source said.