She told UK's Daily Mail she is one of the few actresses over the age of 30 who hasn't had any work done - and she's gonna stay that way.
"I don’t want to have some hideous surgery that’s not even going to guarantee me any work and could make me unemployable," she said.
"People know how old I am, so it’s OK if I look my age."
She doesn't mind being crossed off a few Christmas card lists either - she slammed the worst surgery culprits by name. Meg Ryan, Melanie Griffith, Sharon Osbourne and even our own Nicole Kidman are in her name-and-shaming line of fire.
"We all know who has and who hasn’t [had surgery]," she said.
There are some who look better than others, but you can tell at 50 paces.
"I don’t blame people for going under the knife. If someone is known as a beauty and a sex symbol, they are under a lot of pressure to keep looking good. But it rarely turns out well. Plastic surgery can age people terribly – it always makes you look older in the end and can ruin careers."
Check out the before-and-after shots of Jane's worst offenders and hear what she had to say:
"Don’t fight ageing," she said. "Do everything you can to look good, but don’t try to look 25 when you’re 52, because we know how old you are."
Growing old gracefully hasn't affected Jane's career - she's starred in a string of hit sitcoms from Frasier to Murphy Brown to new TV hit Hot In Cleveland. And she's still a babe.
Sending the right message to her 12-year-old daughter Isabella is also important to her.
"I don’t want to be suddenly coming home with my face tied up," she said.
"I don’t want Isabella to think that’s what it’s all about. There’s enough pressure on young girls nowadays without them having to worry about that. It just doesn’t send the right message to young women, and that’s a big concern."
For all her celeb-slagging, she's got nothing but nice things to say about the famous women who choose to leave their looks untouched.
"I love looking at a naturally ageing woman," she said. "Look at Helen Mirren, she looks great, and men find her sexy.
"I think maybe Susan Sarandon had a little something done just recently, I don’t know, but she is ageing nicely.
"Meryl Streep is ageing beautifully. I can’t imagine Meryl getting Botox. But again, they’re not known for just being a pretty face, they’re known for having substance."
What about famous plastic surgery horror Joan Rivers?
"I love Joan," she admits. "She owns it, she’s totally honest about it, and that’s the difference. And she makes fun of it."
Jane says Hollywood's surgery fixation is overflowing into the minds of ordinary women.
"It’s not just actresses. Many of the mums at my children’s school suddenly turn up with their faces pulled up to here," she said."It’s just insecurity, and this town breeds it. I catch my kids staring at people sometimes, they call them fish-faces."
Check out some more bizarre celebrity surgery transformations in our WTF happened to your face slideshow!