Appearing on the Graham Norton Show to promote his new film, Rock of Ages, Russell played the guilt card when Graham asked about his failed marriage to Katy Perry.
"My mum is here. She got upset when you dragged up my marriage," Brand blasted, as his mother Barbara sat in the audience.
"I saw her cry, Graham. That's the reality because its real people, Graham, that’s my real mum. I have come here to promote a film and you made my mum cry. I don't see you as that sort of person, Graham," he continued.
There is no trace of the video clip online, and according to YouTube users, the segment was removed from the show when it aired on the BBC.
According to RadarOnline, Graham tried to squirm his way out of the situation, saying it would have been "weird" not to bring up Katy.
But Russell hit back, saying he hadn’t been told beforehand that the interview would feature questions about his personal life.
The 37-year-old comedian was back to his charming ways by the following night, though, when he met the Dalai Lama at a live event in Manchester.
The Buddhist leader described Russell, who played host for the evening, as a "strange, wonderful man."
But Russ couldn't completely erase the memory of his spat with Graham, announcing to the audience, "Someone was rude to me. I was angry. I can forgive the human being but not the action."
We're not sure whether the largely Buddhist audience could have cared less about a tiff between two UK celebrities, but Russell isn't known for being particularly appropriate, is he?